Computational Biology Post Doctorate Fellow, Biomarker Department

Ionis Pharmaceuticals, Inc. is a pioneer in RNA-targeted medicines, seeking a highly motivated Postdoctoral Fellow in their Biomarker group. The role involves developing and implementing biomarker strategies, analyzing proteomic and EEG data, and collaborating with external partners to support neurology programs.

Responsibilities

• Responsible for working with collaborators and within the Biomarker group to access, harmonize, and analyze various proteomics data as well as EEG data
• Independently design and deploy computational pipelines to process and analyze proteomics and EEG data
• Communicate in an effective and timely manner with team members regarding project status, timelines, and analysis updates
• Integrate findings from omics datasets to support Ionis programs
• Participate in Ionis collaborations to access and contribute to additional datasets for application to related projects

Skills

• Bioinformatician with PhD in computational biology or related field
• Critical-thinking and problem-solving skills with attention to detail
• Experience devising, designing, and executing scientific experiments and projects
• Expected experience includes working with multi-modal omics datasets and large proteomic datasets (O-link, untargeted LC-MS data, etc), evidenced by high-impact publications
• Applicants should be proficient in R, Python or another appropriate programming language for analysis of processed proteomics data (e.g. SomaScan, label-free or TMT mass spectrometry), including data wrangling, QC, normalization, and differential protein abundance testing
• Experience with packages such as tidyverse, MSstats, DEP2, pandas, numpy, and scikit-learn, as well as pathway and network analysis tools (e.g. GSEA/fgsea, clusterProfiler), is highly desirable
• Ability to multi-task and manage several projects in parallel
• Work collaboratively and productively in fast-paced cross-functional teams
• Excellent communicator who is comfortable presenting in cross-functional meetings and maintaining open and effective lines of dialogue, addressing problems and collaborating constructively with team members
• Must be organized, adaptive, and detail oriented, with the ability to multitask, and manage multiple tasks in parallel with competing priorities
• Proven ability of being productive and successful in an intense work environment
• Candidate must be in San Diego or willing to relocate (fully onsite or hybrid)
• Travel minimal 0-10%
• Degree and/or background working on neurological diseases and/or biomarker discovery would be a plus
• Experience handling EEG data is not required
• The following experience would be beneficial but is not essential: Running assays such as targeted protein ELISAs to validate computational findings

Benefits

• Ionis offers an excellent benefits package!

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